SE440596B - Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin - Google Patents
Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobinInfo
- Publication number
- SE440596B SE440596B SE8002591A SE8002591A SE440596B SE 440596 B SE440596 B SE 440596B SE 8002591 A SE8002591 A SE 8002591A SE 8002591 A SE8002591 A SE 8002591A SE 440596 B SE440596 B SE 440596B
- Authority
- SE
- Sweden
- Prior art keywords
- heme
- mixture
- ethanol
- volume
- concentrate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 87
- 239000012141 concentrate Substances 0.000 title claims description 56
- 239000008280 blood Substances 0.000 title claims description 33
- 239000000126 substance Substances 0.000 title claims description 33
- 210000004369 blood Anatomy 0.000 title claims description 30
- 238000000034 method Methods 0.000 title claims description 18
- 102000001554 Hemoglobins Human genes 0.000 title claims description 15
- 108010054147 Hemoglobins Proteins 0.000 title claims description 15
- 238000011084 recovery Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 219
- 150000003278 haem Chemical class 0.000 claims description 140
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 93
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 28
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 238000000605 extraction Methods 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 239000004471 Glycine Substances 0.000 claims description 14
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 102000018146 globin Human genes 0.000 claims description 9
- 108060003196 globin Proteins 0.000 claims description 9
- 238000000926 separation method Methods 0.000 claims description 9
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 238000003776 cleavage reaction Methods 0.000 claims description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000007017 scission Effects 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 3
- 235000019270 ammonium chloride Nutrition 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 235000015424 sodium Nutrition 0.000 claims description 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 3
- 229940095064 tartrate Drugs 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 57
- 239000007858 starting material Substances 0.000 description 46
- 239000006228 supernatant Substances 0.000 description 37
- 210000000601 blood cell Anatomy 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 20
- 238000003756 stirring Methods 0.000 description 13
- 238000001816 cooling Methods 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 11
- 229910052742 iron Inorganic materials 0.000 description 11
- 239000002244 precipitate Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 239000005457 ice water Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000001166 ammonium sulphate Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 235000015927 pasta Nutrition 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 206010022971 Iron Deficiencies Diseases 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 2
- 229940025294 hemin Drugs 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 235000021395 porridge Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- JQRLYSGCPHSLJI-UHFFFAOYSA-N [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical compound [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 JQRLYSGCPHSLJI-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 125000001095 phosphatidyl group Chemical group 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/017—Hydrolysed proteins; Derivatives thereof from animals from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002591A SE440596B (sv) | 1980-04-03 | 1980-04-03 | Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin |
| IE644/81A IE51040B1 (en) | 1980-04-03 | 1981-03-24 | Heme concentrate and method for the preparation thereof |
| AT81900824T ATE15972T1 (de) | 1980-04-03 | 1981-04-01 | Heme-konzentrat und verfahren zu dessen herstellung. |
| JP56501036A JPH0134204B2 (en]) | 1980-04-03 | 1981-04-01 | |
| AU69226/81A AU541882B2 (en) | 1980-04-03 | 1981-04-01 | Heme concentrate and method for the preparation thereof |
| EP81900824A EP0056025B1 (en) | 1980-04-03 | 1981-04-01 | Heme concentrate and method for the preparation thereof |
| PCT/FI1981/000026 WO1981002834A1 (en) | 1980-04-03 | 1981-04-01 | Heme concentrate and method for the preparation thereof |
| DE8181900824T DE3172573D1 (en) | 1980-04-03 | 1981-04-01 | Heme concentrate and method for the preparation thereof |
| US06/324,395 US4431581A (en) | 1980-04-03 | 1981-04-01 | Heme concentrate and method for the preparation thereof |
| IN371/CAL/81A IN152639B (en]) | 1980-04-03 | 1981-04-02 | |
| FI813749A FI65369C (fi) | 1980-04-03 | 1981-11-24 | Foerfarande foer framstaellning av heme-koncentrat |
| DK530181A DK154266C (da) | 1980-04-03 | 1981-11-30 | Fremgangsmaade til fremstilling af et haem-koncentrat fra en blanding af haem og blodsubstans opnaaet ved spaltning af haemoglobin |
| SU813359217A SU1660573A3 (ru) | 1980-04-03 | 1981-11-30 | Способ получени концентрата гема |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8002591A SE440596B (sv) | 1980-04-03 | 1980-04-03 | Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8002591L SE8002591L (sv) | 1981-10-04 |
| SE440596B true SE440596B (sv) | 1985-08-12 |
Family
ID=20340685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8002591A SE440596B (sv) | 1980-04-03 | 1980-04-03 | Forfarande for framstellning av ett heme-koncentrat ur en blandning av heme och blodsubstans erhallen vid spaltning av hemoglobin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4431581A (en]) |
| EP (1) | EP0056025B1 (en]) |
| JP (1) | JPH0134204B2 (en]) |
| DK (1) | DK154266C (en]) |
| IE (1) | IE51040B1 (en]) |
| IN (1) | IN152639B (en]) |
| SE (1) | SE440596B (en]) |
| SU (1) | SU1660573A3 (en]) |
| WO (1) | WO1981002834A1 (en]) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2548671B1 (fr) * | 1983-07-07 | 1986-05-02 | Merieux Inst | Procede de preparation de globine a partir d'hemoglobine et globine obtenue par ce procede |
| FI68970C (fi) * | 1983-08-10 | 1985-12-10 | Medica Pharma Co Ltd | Foerfarande foer framstaellning av en ny medicinskt anvaendbarhemin-foerening |
| US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
| FR2714380B1 (fr) * | 1993-12-24 | 1996-05-24 | Bioxytech | Utilisation de dérivés 2-mercapto-imidazole substitués en position 4 (ou 5) comme agents antioxydants, leur procédé de préparation et leurs applications en pharmacie, cosmétique ou alimentaire. |
| DK0946563T3 (da) * | 1996-12-20 | 2002-11-04 | Fraunhofer Ges Forschung | Fremgangsmåde til udvinding af hæmatitjern fra slagteblod |
| US6845820B1 (en) * | 2000-10-19 | 2005-01-25 | Weatherford/Lamb, Inc. | Completion apparatus and methods for use in hydrocarbon wells |
| US6749872B2 (en) * | 2002-02-01 | 2004-06-15 | The Lauridsen Group Incorporated | Heme supplement and method of using same |
| CN102599332B (zh) * | 2012-03-09 | 2014-07-30 | 上海杰隆生物制品股份有限公司 | 一种利用禽血生产低灰分禽血浆蛋白粉的方法 |
| CN103536670A (zh) * | 2013-10-17 | 2014-01-29 | 新疆天海绿洲农业科技股份有限公司 | 一种改善营养性贫血的组合物及其制备方法 |
| CN103610828B (zh) * | 2013-12-10 | 2015-10-28 | 王怀兰 | 治疗女性贫血中药组合物及制备方法 |
| KR20180079846A (ko) | 2017-01-03 | 2018-07-11 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 생물학적 방법 |
| KR101894575B1 (ko) | 2017-01-03 | 2018-09-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법 |
| US20250109161A1 (en) * | 2021-11-30 | 2025-04-03 | National University Of Singapore | Heme, compositions and method of synthesis thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7715575A (en) * | 1974-01-08 | 1976-07-08 | Commw Scient Ind Res Org | Separation of protein from blood |
| AU492555B1 (en) * | 1974-01-08 | 1976-07-08 | Commonwealth Scientific And Industrial Research Organization | Separation of protein from blood |
| SE389596B (sv) * | 1974-06-14 | 1976-11-15 | P G S Lindroos | Saett att ur en vaetska innehallande blodsubstanser separera jaernfoereningar fran globin |
| SE7513987L (sv) * | 1975-12-11 | 1977-06-12 | Paul Goran Sigvard Lindroos | Sett att behandla vetskor innehallande blodsubstanser |
| US4098780A (en) * | 1975-06-04 | 1978-07-04 | Paul Goran Sigvard Lindroos | Method of treating liquids containing blood substances |
| CA1126653A (en) * | 1978-12-22 | 1982-06-29 | Jan H. Luijerink | Process of preparing blood cell protein and heme from hemoglobin |
-
1980
- 1980-04-03 SE SE8002591A patent/SE440596B/sv not_active IP Right Cessation
-
1981
- 1981-03-24 IE IE644/81A patent/IE51040B1/en unknown
- 1981-04-01 JP JP56501036A patent/JPH0134204B2/ja not_active Expired
- 1981-04-01 US US06/324,395 patent/US4431581A/en not_active Expired - Fee Related
- 1981-04-01 WO PCT/FI1981/000026 patent/WO1981002834A1/en active IP Right Grant
- 1981-04-01 EP EP81900824A patent/EP0056025B1/en not_active Expired
- 1981-04-02 IN IN371/CAL/81A patent/IN152639B/en unknown
- 1981-11-30 DK DK530181A patent/DK154266C/da not_active IP Right Cessation
- 1981-11-30 SU SU813359217A patent/SU1660573A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1660573A3 (ru) | 1991-06-30 |
| WO1981002834A1 (en) | 1981-10-15 |
| IE51040B1 (en) | 1986-09-17 |
| IN152639B (en]) | 1984-02-25 |
| DK154266B (da) | 1988-10-31 |
| DK530181A (da) | 1981-11-30 |
| IE810644L (en) | 1981-10-03 |
| EP0056025A1 (en) | 1982-07-21 |
| SE8002591L (sv) | 1981-10-04 |
| JPH0134204B2 (en]) | 1989-07-18 |
| JPS57500431A (en]) | 1982-03-11 |
| DK154266C (da) | 1989-03-28 |
| US4431581A (en) | 1984-02-14 |
| EP0056025B1 (en) | 1985-10-09 |
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